Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Leander / Matthew MacDell (voice)

Jenny Slate

Pharmacist / Caitlin (voice)

Joe Wengert

Caleb / Go-Gurt Thief / Teacher (voice)

Ayo Edebiri

Missy Foreman-Greenwald (voice)

June Diane Raphael

Devin (voice)

Richard Kind

Marty Glouberman (voice)

Paula Pell

(voice)

Neil Casey

Detective Dumont / Lars (voice)

Jessica Chaffin

Jon Daly

Jak Knight

DeVon (voice)

Chelsea Peretti

Diaphragm (voice)

Seth Morris

Greg Glaser (voice)

Mark Rivers

Michael Stipe Tampon (voice)

Gil Ozeri

The Ponytail Killer / Pornscape Residents (voice)

Nathan Fillion

Kat Dennings

Leah Birch (voice)

Gina Rodriguez

Gina Alvarez / Gina Parrot (voice)

David Thewlis

Lionel St. Swithens (voice)

Thandiwe Newton

Mona (voice)

Heather Lawless

Jenna Bilzerian (voice)

Maria Bamford

Brandon Kyle Goodman

Walter the Lovebug (voice)

Mark Duplass

Whitmer Thomas

Camden (voice)

Paul Scheer

Kurt Bilzerian (voice)

Ali Wong

Ali (voice)

Zachary Quinto

Stephanie Beatriz

Lulu (voice)

Emily Altman

Olivia / Filmstrip Narrator (voice)

Chloe Fineman

Leah Birch (voice)

Rob Huebel

Mr. Lizer (voice)

Natasha Lyonne

Suzette (voice)