Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Matthew (voice)

Jenny Slate

Joe Wengert

Caleb / Pornscape Residents (voice)

Ayo Edebiri

Missy Foreman-Greenwald / Mosaic Missy (voice)

June Diane Raphael

Devin (voice)

Richard Kind

Marty Glouberman (voice)

Jessica Chaffin

Shannon Glaser (voice)

Paula Pell

Barbara Glouberman / Lola's Couch Pillow (voice)

Neil Casey

(voice)

Jon Daly

Judd Birch / Pumbaa (voice)

Jak Knight

DeVon

Chelsea Peretti

Monica Foreman-Greenwald (voice)

Seth Morris

Mark Rivers

Michael Stipe Tampon (voice)

Gil Ozeri

Wiggles (voice)

Nathan Fillion

Kat Dennings

Leah Birch (voice)

Gina Rodriguez

Gina Alvarez (voice)

David Thewlis

Shame Wizard (voice)

Thandiwe Newton

Mona (voice)

Maria Bamford

Tito the Anxiety Mosquito (voice)

Heather Lawless

Brandon Kyle Goodman

Mark Duplass

Val Bilzerian (voice)

Whitmer Thomas

Paul Scheer

Ali Wong

Ali (voice)

Zachary Quinto

Aiden (voice)

Stephanie Beatriz

Lulu (voice)

Emily Altman

Chloe Fineman

Rob Huebel

Mr. Lizer (voice)

Natasha Lyonne

Ms. Dunn (voice)