Les Razmoket

E. G. Daily

Tommy Pickles (voice)

Kath Soucie

Phil DeVille / Lil DeVille (voice)

Cheryl Chase

Angelica Pickles (voice)

Melanie Chartoff

Didi Pickles (voice)

Jack Riley

Stu Pickles (voice)

Michael Bell

Drew Pickles / Chas Finster (voice)

Tress MacNeille

Charlotte Pickles (voice)

Cree Summer

Susie Carmichael (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Joe Alaskey

Lou Pickles (voice)

David Doyle

Lou Pickles (voice)

Tara Strong

Timmy McNulty / Teddy McNulty (voice)

Dionne Quan

Kimi Finster (voice)

Julia Kato

Kira Finster (voice)

Phil Proctor

Intern / Dr. Lecter (voice)

Nancy Cartwright

Boy / Brat / Nick (voice)

Tony Jay

Rich Man (voice)

Debbie Reynolds

Lulu Johnson (voice)

Dana Hill

Josh (voice)

Scott Menville

Batboy / Bucky Majors (voice)

Amanda Bynes

Taffy (voice)

Andrea Martin

Aunt Miriam / Woman (voice)

Neil Ross

Announcer / Columnist / Fisherman (voice)

Pamela Adlon

Wiseguy (voice)

Danny Mann

Reptar / Operator (voice)

Ron Glass

Randy Carmichael (voice)

Gregg Berger

Metalitron / Marco (voice)

Jim Turner

Ricky (voice)

Hattie Winston

Lucy Carmichael / Lucy's Mom (voice)

Jeremy Piven

Mailboy / Lawyer #2 (voice)

Grey DeLisle

Terry McNulty / Todd McNulty / Ty McNulty (voice)

Pat Musick

Harold Frumpkin (voice)

Andy Houts

Bucky / Policeman (voice)

Candi Milo

Tippy / Red Shirt Kid (voice)

Hope Levy

Britannica / Cheerleader / Frenzied Fan (voice)

Dan Castellaneta

Hershowitz / Jury Foreman / Press (voice)

Bettina Bush

Alisa Carmichael (voice)

Erv Immerman

Radio Announcer (voice)

Cheryl Carter

Lucy Carmichael (voice)

Jesse Corti

Reptar / Knight (voice)