Les Razmoket

E. G. Daily

Tommy Pickles (voice)

Kath Soucie

Phil DeVille / Lil DeVille (voice)

Cheryl Chase

Angelica Pickles (voice)

Melanie Chartoff

Didi Pickles (voice)

Jack Riley

Stu Pickles (voice)

Michael Bell

Drew Pickles / Chas Finster (voice)

Tress MacNeille

Charlotte Pickles (voice)

Cree Summer

Susie Carmichael (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Joe Alaskey

Lou Pickles (voice)

David Doyle

Lou Pickles (voice)

Tara Strong

Giggling Baby (voice)

Dionne Quan

Kimi Finster (voice)

Phil Proctor

Announcer / Driver #1 / Tour Guide (voice)

Nancy Cartwright

Chuckie Finster (voice)

Tony Jay

Wombat President / Dr. Lipschitz (voice)

Dana Hill

Little Kid (voice)

Scott Menville

Batboy / Bucky Majors (voice)

Amanda Bynes

Taffy

Neil Ross

Real Santa / Announcer / Clerk (voice)

Danny Mann

Adman #2 (voice)

Pamela Adlon

Baby Drew Pickles (voice)

Gregg Berger

Dr. Prescott (voice)

Jim Turner

New Baby / Benjy (voice)

Ron Glass

Randy Carmichael (voice)

Jeremy Piven

#12 (voice)

Andrea Martin

Aunt Miriam / Woman (voice)

Candi Milo

Tippy (voice)

Andy Houts

Oodles (voice)

Pat Musick

Edwin Carmichael (voice)

Grey DeLisle

Terry McNulty / Todd McNulty (voice)

Cheryl Carter

Lucy Carmichael (voice)

Jesse Corti

Serenader (voice)

Mona Marshall

Clarice Pendagron / Checkout Girl (voice)

Hattie Winston

Lucy Carmichael (voice)

Debbie Reynolds

Lulu Pickles (voice)

Vicki Lewis

Miss Carol (voice)

David Eccles

Krumm / Giant Head Monster (voice)

Charlie Adler

Ickis / Cyclops Monster / Ghost (voice)

Julia Kato

Kira Finster (voice)